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Applied sciences for manufacturing therapeutic monoclonal antibodies have matured within the many years for the reason that first therapy was accredited, however there are nonetheless workflow challenges that should be addressed. Producing these biologics requires constant and repeatable processes. Nevertheless, a vital step—tangential circulate filtration (TFF)—stays an necessary supply of variability. Standard TFF methods that depend on cassette holders and torque-based set up are susceptible to setup inconsistencies that may have an effect on yield and cut back reproducibility. Newer designs tackle these points, serving to producers work extra effectively and constantly.
On this GEN webinar, Mark Perreault will focus on methods for bettering mAb manufacturing utilizing the most recent applied sciences for separating, purifying, and concentrating therapeutic biomolecules. He’ll current case research that illustrate a brand new flat-sheet holder-less TFF design for multi-use workflows together with knowledge demonstrating the advantages of the design, together with decreased operator errors and shorter setup time. You’ll additionally find out how the up to date design removes the necessity for cassette holders and permits uniform circulate distribution throughout the membrane floor whereas minimizing torquing and product loss.
Key takeaways embrace:
• How a holder-less design improves course of reliability by eliminating set up points and lowering operational complexity.
• How the design affords seamless scalability, because the gadget maintains constant channel path lengths and stress drop profiles throughout cassette codecs.
• How uniform circulate distribution enhances product yield and reduces variability in efficiency.
• How separation effectivity, flux charges, and fouling resistance of holder-less designs evaluate to conventional cassettes.
A reside Q&A session will comply with the shows, providing you an opportunity to pose inquiries to our professional panelists.
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