What’s up with Vitalik? Why Gen Z loves ‘Particular Ok,’ BTC to hit $150K, Right here come the AI bots, Vinod Ok says 80% of jobs are mud by 2030, and different hits that can blow your thoughts…
The poster kids of PC had been Steve Jobs and Invoice Gates. Web1 was all concerning the WWW inventor Tim Berners-Lee, Web browser pioneer Marc Andreessen, Mr. E-commerce Jeff Bezos, and the Google Search twins. Web2 was ushered in by the conspicuously unsocial social innovators Zuck and Jack Dorsey, the overly social Queen of SaaS Marc Benioff, and the comeback of Steve Jobs, who put the Web in our pockets with a smart-looking smartphone.
The issue with Web3 is that we solely have a pseudonym for our major disruptor, ‘Satoshi Nakamoto’, who represents the one (or extra) inventors nonetheless hiding someplace, holding their ~1 million BTC reward for his or her early efforts. The quantity two dude of the revolution is our boy pictured up prime—Ethereum cofounder Vitalik Buterin—who, if for no different cause, suits the crypto look (and pioneered the world’s second-largest blockchain by market cap—ETH).
Vitalik was born in 1994 in Kolomna, Russia, and raised in Canada after emigrating at age six. In 2013, at simply 19 years previous, he printed the Ethereum whitepaper, proposing a programmable blockchain that prolonged Bitcoin’s capabilities past easy transactions to incorporate programmable good contracts. Our easy view is that the mix of the ‘Bitcoin metaphor’ of decentralized energy, self-executing code, and the fusion of crypto and AI makes the Web1 and Web2 eras seem like we had been taking part in with Tinker Toys.
At the moment, Vitalik pushes moral growth, layer-2 scalability, and decentralized governance—shaping Ethereum and Web3 amid evolving rules and explosive adoption.
“The decentralized future is not only about creating new functions; it’s about rethinking how we set up society. You shouldn’t need to belief any single particular person, establishment, or centralized group to transact and get issues achieved.” —VB
Vitalik at present holds roughly 224,000 ETH in his tracked on-chain wallets; this equates to roughly $430–$467 million in worth from his major ETH holdings. (We’re sure he owns a boatload extra in off-chain storage someplace.) He actively reinvests his wealth into the Ethereum ecosystem, privateness instruments, protocol analysis, AI security, medical analysis, and humanitarian assist. Right here’s a pattern:
India COVID-19 Reduction (2021): $1B+ in SHIB/ETH for pandemic assist—one in every of crypto’s largest.
Way forward for Life Institute (AI Security, 2021): $665M in crypto for AI dangers and alignment.
Methuselah Basis (Longevity, 2021): $336M in ETH/tokens for anti-aging analysis.
U. Maryland Public Well being (2022): $9.4M USDC for UV mild pandemic prevention.
Session/SimpleX (Privateness, 2025): $765K ETH for safe messaging apps.
Kanro Charity (AI/Well being, 2025): $500K ETH/USDC for AI dangers, open-source, and world well being.
Vitalik’s massive imaginative and prescient for Ethereum: A “world pc” for a freer web by way of decentralization, privateness, and utility. Attaining full self-sovereignty by way of low-risk DeFi, censorship resistance, scalable decentralized instruments for citizen ID, voting techniques, and all authorities providers.
In case you are a cypherpunk developer aligned with the tasks that embody Vitalik’s beliefs, it’s time to ship him your pitch. @VitalikButerin
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San Francisco’s eating places are signaling an alcohol freefall, with gross sales plunging 30%—mirroring nationwide developments. Gen Z’s 20% decrease consumption fee is accelerating the bleed. This shift can be hammering California’s wine trade with brutal drive: an oversupply and cratering demand sparked 81 vineyard closures in 2025, plus mass layoffs and restructuring at Gallo and others. A Silicon Valley Financial institution report predicts 3-5% annual declines by way of 2028 except wineries pivot laborious to non-alcoholic alternate options or exports.
Cryptonite’s go-to well being guru, Dr. Franck Lipman—a prime useful drugs skilled—warns that even average alcohol harms well being and longevity throughout a number of techniques. Dr. Lipman urges quitting alcohol for higher vitality and an extended healthspan.
Accelerates growing older: Oxidative stress speeds mobile decline and age-related ailments.
Most cancers threat: Boosts breast most cancers by way of hormones and toxins.
Intestine disruption: Causes dysbiosis, irritation, fatty liver, and insulin resistance.
Immune weakening: Slows reflexes and will increase susceptibility to an infection.
Mind/sleep hurt: Impairs cognition, hormones, and sleep; hyperlinks to dementia and melancholy.
Surveys reveal 63% of Gen Z adults have misplaced curiosity in booze since their first sip, pushed by well being consciousness, private economics, shifting social vibes, and a longing for clear-headed residing. Hop waters, tea-based sippers, low-sugar CBD-infused sodas, premium mocktails, and zero-proof beer and wines are exploding. Suppose spirit-free wonders from Curious Elixirs and Ghia, full of botanicals and adaptogens for that mood-lift kick.
Gallup information exhibits simply 50% of 18-34-year-olds now drink, down from 59% two years in the past, whereas U.S. ingesting charges amongst authorized adults have crashed to a historic low of 54%. Hashish can be a most popular different for Gen Z to realize an elevated state: surveys present ~69% of younger adults aged 18-24 favor marijuana over alcohol, with cannabis-infused sodas, edibles, and vapes gaining traction for ‘highs with out hangovers.’
For the ‘sober curious’ looking for Insta-worthy aesthetics
Watermelon-Basil Cooler (Watermelon Sugar Excessive): Muddled watermelon, lime, and basil topped with glowing water—crisp, herbaceous refreshment that’s clear, photogenic, and wellness vibes solely.
🤤
Spicy Mango Mule: Mango puree, contemporary lime, and fiery ginger beer in a copper mug—daring kick mimics booze with vibrant, aesthetic-first attract.
Blood Orange Elderflower Spritz: Vibrant blood orange and floral elderflower fizz for brunch or sober dates—subtle, bubbly botanicals that pop in images.
Different alternate options embrace exploring psychedelics in therapeutic or leisure contexts, resembling psilocybin microdosing for psychological readability. Ketamine (known as ‘Ok’ or ‘Particular Ok’) use as a dissociative ‘floaty’ excessive amongst Gen Z has tripled for the reason that mid-2010s, providing a perceived momentary escape from stress, nervousness, or melancholy. Nevertheless, frequent use of Ok can result in dependancy, bladder injury (generally requiring surgical procedure), kidney points, incontinence, and even fatalities in excessive instances.😳
Ketamine nasal spray is available in two types: the FDA-approved esketamine (Spravato), a prescription nasal spray derived from ketamine for treatment-resistant melancholy, and compounded or illicit variations generally obtained outdoors medical channels. The attraction is fast symptom aid—generally inside hours—in comparison with conventional antidepressants.
All this well being consciousness laced with ‘Ok’ has left Gen Z with nervousness (round 30% prevalence) and melancholy (22%) stats larger than these of earlier generations. Almost half (46%) have a recognized situation, and 94% report common challenges. However take coronary heart.💜 Gen Z optimism is on the rise—over 50% now describe largely good psychological well being days, up from prior years. We suppose that because the COVID-19 hysteria and isolation reminiscences fade, the psychological restoration will enhance. Allow us to pray. 🙏🏼
Melting pot of cryptos.
Once we predicted in December that the crypto market cap would exceed $5 trillion by the top of 2026, the market cap was $3T and BTC was at $87K. Now it’s ~$2.4T and $67K. Principally, the crypto meltdown that began on October sixth—when BTC hit $126K—saved melting.
Cryptonite’s predictions for 2026: OpenAI down, cryptos and IPOs up, a Persian Empire comeback, DeepSeek as CCP instrument, private AI guidelines, LatAm rockin’, EU sucks, and extra hassle…
Institutional Circulate Momentum: Spot Bitcoin ETFs recorded $506M in inflows on Feb 25 (largest in three weeks), amid projections of Vanguard’s entry and sustained demand; Ethereum’s DeFi growth and real-world asset (RWA) tokenization progress are additionally driving large-cap momentum.
State BTC Reserves: Missouri superior HB 2080, enabling voluntary BTC holdings, tax funds in bitcoin, and chilly storage mandates; Texas funded the primary state BTC reserve final 12 months, Arizona superior a multi-token invoice this week, and a number of states are following go well with.
Regulatory Progress: Current SEC case drops are paving the best way for the Digital Asset Market Readability Act, anticipated in early 2026, which guarantees to finish “regulation by enforcement” and increase confidence in belongings like Solana and Chainlink.
Sector Catalysts: Stablecoins are poised to surpass $500B in market cap as key fee infrastructure expands globally; RWAs are set to raise Ethereum towards $6.5K–$7.5K and XRP past $2.80; Bitcoin faces dangers of a $40K–$50K dip if macro weakens, although This autumn upside stays sturdy.
Macro Tailwinds: Dovish Federal Reserve fee cuts mixed with greenback weak point are positioning Bitcoin as a premier hedge towards fiat debasement, with a possible Q2 liquidity surge able to elevating the whole altcoin market cap to $2T
Current $317M token unlocks—like Jupiter’s $36M and Sui’s $40M—sparked short-term promoting strain, however March brings the 12 months’s largest at over $6B (led by WhiteBIT), almost triple the month-to-month common—so count on volatility earlier than a surge in regulatory-approved new listings.
Cryptonite Crypto Targets: Bitcoin might exceed $150K as a cycle-breaker, fueled by ETF and institutional demand; Ethereum $6.5K–$7.5K on RWA and DeFi progress; alts towards a $2T+ market cap by way of selective rotation, with AI/omnichain tasks outperforming BTC by 20–50%. Stablecoins purpose for $500B+, XRP previous $2.80. Draw back dangers: BTC dips to $40K–$50K or March unlocks amid macro weak point—but Q3–This autumn developments favor upside as catalysts activate.
If all our goals (and targets) come true, we’ll blow by way of our $5T crypto market cap prediction for the 12 months. 😎🤙🏼
💸 Michael Saylor doubles down—MicroStrategy buys one other 5K BTC, calls fiat ‘melting ice dice’…
⚖️ SEC drops Coinbase case—paves approach for SOL ETF approvals, Chainlink oracles shine in RWA performs…
⚠️ Macro alert: Powell indicators March rate of interest cuts—alts eye $2T cap if liquidity floods, however BTC dangers $50K dip...
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Private AI bots (digital companions) are clever software program techniques powered by AI—usually leveraging LLMs, pure language processing, and generally on-device processing—to assist people handle each day duties, increase productiveness, and increase cognition in extremely customized methods.
Not like conventional chatbots, AI bots will be reactive—executing instructions like scheduling or note-taking—or proactive/agentic, autonomously dealing with workflows, prioritizing actions, and studying person habits. Right here’s an inventory of probably the most lively VCs in AI bots, with their prime portfolio firms:
Draper Associates (led by Tim Draper) has a Sturdy emphasis on AI (over 40% of portfolio), together with agentic/interactive bots, speech AI, and private assistants. Makes use of AI internally, together with digital twins/chatbot variations of Tim Draper for founder interactions.
Otter.ai — AI speech recognition for conversational notes/conferences.
Omi — an AI wearable as a private assistant/reminiscence assist.
Huxe — AI-powered dwelling providers assistant.
Increase VC(led by Adam Draper) is a deep tech pre-seed give attention to AI brokers, voice AI, and conversational bots.
Deepgram — Voice AI for real-time speech-to-text/text-to-speech in bots/brokers.
Volley — Voice AI for interactive video games/leisure bots.
Potato AI — Autonomous AI brokers for analysis acceleration.
Y Combinator (YC) is the main accelerator with 140+ AI assistant startups; it focuses on no-code, agentic, on-device, and cell AI.
Martin — Superior AI private assistant (like Jarvis) for calendar/inbox/duties.
April — Voice AI govt assistant for e mail/calendar.
kapa.ai — AI bots for technical assist/onboarding.
Andreessen Horowitz (a16z) leads in generative/on-device AI; $12B+ in AI funding for infrastructure, coding assistants, and private intelligence.
Sequoia Capital has a powerful AI portfolio (2,000+ firms); it targets private productiveness, on-device AI, and assistants.
Harvey — AI authorized assistant for safe on-device docs.
Notion — Productiveness instrument with built-in AI assistants.
Cove —Collaborative AI thought companion/assistant.
Khosla Ventures has invested $12.4B in AI; early-stage edge/on-device AI, well being assistants.
Accel is lively in AI coding/engineering instruments; co-led rounds in assistants.
Cursor (Anysphere) — AI coding instrument with on-device effectivity.
Leo AI — AI copilot for mechanical engineers (on-device sketches/searches).
Graphite (acquired by Cursor) — AI collaboration for builders.
Index Ventures targets world AI-native functions and enterprise instruments, with a give attention to seed-to-growth bets in authorized AI, healthcare brokers, gross sales automation, and foundational fashions that energy scalable workflows.
Hippocratic AI — Healthcare AI brokers for affected person interactions and compliance.
Artisan AI — Autonomous gross sales brokers dealing with prospecting and bookings.
Index Accomplice Nina Achadjian likes industrial AI brokers and robots.🤖
Greylock Companions emphasizes agentic AI and enterprise automation, backing startups that construct autonomous brokers to enhance productiveness, safety, and workflows throughout sectors resembling gross sales, healthcare, and infrastructure.
Adept AI — Agentic AI lab growing general-purpose productiveness brokers.
Netic — Autonomous AI income engine for important providers companies.
SuperMe — AI-native skilled community with prompt skilled solutions.
GV (Google Ventures)focuses on transformative AI throughout client and enterprise, with bets on foundational fashions, voice interfaces, and customized intelligence platforms designed for on-device and scalable deployment.
Character.AI — Conversational AI companions for customized interactions.
Inflection AI — Pi, a consumer-facing private AI assistant.
Perplexity AI — On-device AI search and productiveness companion.
💰 a16z leads $250M Sequence B in Bittensor—AI-blockchain fusion for decentralized ML fashions, valuation hits $3B post-money…
💰 AI-Crypto Whispers: Coatue eyes $500M fund for onchain AI infra; Tiger World scouts RWA tokenization startups amid $10T hype….
💥 Paid members get to see the opposite 15 prime crypto firm personal and company VC funding and way more….
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